Lipids & Carbohydrates

Lipids & Carbohydrates


CordenPharma’s scientists have mastered the chemical total synthesis of complex derivatized phospholipids from multi-gram to multi-kilogram scale and are renowned for their contract lipid and phospholipid manufacturing expertise. Our large-scale proprietary cGMP manufacturing processes start with (S)-1,2-isopropylideneglycerol ((S)-IPG) and extend over a cascade of optimised and fully-scalable conversions leading to a wide range of phospholipid molecule derivatives such as, but not limited to:

CordenPharma’s lipid manufacturers also pioneered the chemistry of hydrophilic phospholipids and large-scale manufacture of MPEG-conjugated phospholipids which can be accessed through the same synthesis cascade, rendering them superior quality products in sensitive liposome formulation processes.

In addition, standard cationic phospholipids such as DODMA and DOTAP can be made available in cGMP and R&D grade qualities.

Standard Lipids

A wide selection of Readily Available Lipids Phospholipids suitable for Research & Discovery is available for purchase in convenient 1 g and 10 g pack sizes (please refer to our Lipid List for more details).

To Place An Order For Readily Available Catalog Lipids Please Contact:

Tel +41 61 906-5959
Email [email protected]

BotaniChol® - Non-Animal Cholesterol

As a result of the COVID-19 pandemic in 2020, CordenPharma developed a straightforward, short synthesis of highly pure plant-derived cholesterol called BotaniChol® used in the production of lipids for mRNA vaccines.

Currently, the main quantities of cholesterol for industrial applications are extracted from wool grease of sheep or animal tissues. These sources involve the risk of Transmissible Spongiform Encephalopathies (TSEs) agents via human and veterinary medicinal products.

The new production process of BotaniChol® with non-animal origin cholesterol avoids any potential animal source of contamination, as it is based solely on chemical transformations starting with plant materials. The patented process plays an important role in overcoming the global shortage of lipids, and aiding in the production of more life-saving vaccines around the world to fight the pandemic.

In addition to our standard phosphocholine, pegylated and cationic lipids, BotaniChol® nicely completes our mRNA lipid offering for global partners involved in fighting the pandemic.

Custom Lipid Manufacturing

CordenPharma also offers cGMP contract manufacturing of proprietary lipids, phospholipids, monoglycerols, diacylglycerols, sphingosines, ceramides and engineered cationic lipids to meet our customers’ tailored demand of custom lipid excipients.

Furthermore, CordenPharma is in a unique position to draw upon this combination of chemistry capabilities to synthesize novel liposome conjugate components conjugated with functional peptides or carbohydrates for targeted drug delivery.


CordenPharma is uniquely positioned to provide development and manufacturing services along the value chain ranging from clinical activities through process development, scale-up and GMP manufacturing of Complex Carbohydrates for a wide range of applications, including:

  • >> Glycoconjugate Vaccine Antigens
  • >> Immunomodulatory Therapeutics
  • >> Tissue Targeting / Drug Delivery Motifs
  • >> Carbohydrate-based APIs

CordenPharma provides large-scale cGMP manufacturing at CordenPharma’s facilities in the US and Europe. CordenPharma additionally provides a full range of innovative carbohydrate synthesis and nucleotide derivatives from early-phase through to commercial cGMP manufacturing:

  • >> Manufacturing from tens / hundreds of g to multi-kg Production of
    • >> Di and Trinucleotide
    • >> Cyclic Dinucleotide
    • >> Complex Carbohydrates
      • >> Glycolipid
      • >> GalNac
      • >> Phosphatidylinositol
      • >> Glycopeptide
  • >> Multi-Step Process Engineering Expertise
  • >> Modified and / or Regular Phosphoramidites
  • >> Proven cGMP Production Capabilities for
    • >> Clinical Trial Material
    • >> Commercial API Material

Integrated Supply

CordenPharma’s ability to develop and manufacture Active Pharmaceutical Ingredients (APIs), Finished Dosage and Packaging in our network of facilities allows clients full access to integrated services resulting in a simplified supply chain, reduced risk and cost associated with technology transfers, and ultimately faster production and delivery timelines.