News & Press
Edition 1 / September 2018
Peptides, Lipids & Carbohydrates Platform > Solid Phase Peptide Synthesis Expansion Strengthens Offerings in Brussels & Colorado
Edition 1 / September 2018
Author
Dr. Matthieu Giraud
Director, Global Peptides, Lipids & Carbohydrates Platform,
CordenPharma International
Manufacturing of Peptides at CordenPharma Colorado
A growing number of therapeutic peptides in pipeline and therapeutic indication expansions for peptides are the key drivers for capacity expansion by leading CDMOs (Contract Development & Manufacturing Organizations) in the global peptide API market. Although the early peptides were hormones, therapeutic peptides are now being developed for almost every therapeutic category ranging from anti-inflammatory to cancer therapeutics. Furthermore, CDMOs are focusing on internal and external capacity expansion and integration into the pharma supply chain, which ultimately increases contract manufacturing activities for peptide APIs across the globe.
The global peptide API market is estimated to be valued at US $1,700 Million in 2018, and likely to expand at a CAGR of 7.7% over the forecast period (2018–2025) to reach US 2,900 Million by 2025.
CordenPharma has assembled a wealth of experience (over 30 years for our EU site CordenPharma Brussels (BE) and over 20 years for our North American site CordenPharma Colorado (US)) and expertise in the development of peptide manufacturing under the Peptides, Lipids & Carbohydrates Platform, using both LPPS (Liquid Phase Peptide Synthesis) and SPPS (Solid Phase Peptide Synthesis) technologies.
Our Colorado facility, with approximately 250 employees, has grown a strong focus in the development and manufacturing of APIs from laboratory scale to commercialization at tons scale, thanks to our unique large scale SPPS capabilities. CordenPharma Colorado owns the largest SPPS equipment available, which is used in the manufacturing of peptide fragments up to a ton per batch. The purification of the final peptide can be performed at any scale from 5 cm to 100 cm columns, with 100 cm being the largest worldwide high pressure reverse phase column. To avoid the tedious and poor productivity of the final isolation step by lypohilization, their development team gained an unmatched expertise in peptide precipitation that has been successfully transferred to production in commercial products. The site has a long track record in large scale manufacturing, where all potencies including picogram levels can be reached.
CordenPharma Brussels specializes in the development and manufacturing of peptides using both LPPS and SPPS technologies. In the 1980s, nearly all peptides entering clinical development were fewer than 10 amino acids long (Oxytocin 1962, Leuprolin 1984, Octreotide 1988). The average peptide length has increased with each subsequent decade, largely due to improvements in peptide synthesis and manufacturing technology. A broadened range of popular molecular targets, including B class GPCRs that are activated by larger peptide ligands, has also played a role. Development candidates are more equally distributed in the various length ranges up to 40 amino acids, meaning that they are mostly being produced by SPPS. To follow the market dynamic and better support our customers, CordenPharma is investing in expanded capabilities in CordenPharma Brussels by increasing its SPPS capacity with automated equipment. CordenPharma facilities are regularly inspected by all major regulatory agencies and routinely supply to all regulated markets.
With an integrated network of multiple cGMP manufacturing facilities across Europe and North America, and a unique combined expertise in Peptides, Carbohydrates & synthetic Lipids leveraging our deep pharma legacy, CordenPharma provides access to a wide range of products in a full vertical offering, from back integration of early intermediates and large scale API production to finished dosage Drug Product development & manufacturing.
Stay up to date with the latest thought leadership articles and news from CordenPharma.
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#CordenPharmaBoulder #CordenPharmaColorado
Celebrations included a garden party with a festive banquet of foods from Italy, Germany, France, & US, games, marshmallow roasting, custom beer steins and other 15 Year gifts, and balloons stuffed with prizes. All employees then heard a speech from Managing Director Brian McCudden and COO Dr. Lee Newton.
#CordenPharmaBergamo
Celebrations included a garden party with German-themed breakfast, lunch or dinner buffets, 15 Year custom cakes and gifts distributed to all employees, along with a speech from Managing Director Luca Porcu and VP of Platform Management & Marketing Stephen Houldsworth.
#CordenPharmaSwitzerland
Celebrations included an introduction of our core values, followed by playful games to implement them, distribution of 15 year bags, food and a live band in a garden party. Employees heard from Managing Director Dr. Juerg Burger and VP of Human Resources Stefanie Gerber.
#CordenPharmaPlankstadt
Celebrations were split into 3 groups to cover all shifts and included a festive room with a 3 course buffet meal, 15 Year custom gift bags with locally-brewed beer, and a welcome speech by Site Business Development Christina Simons and CEO Dr. Michael Quirmbach.
#CordenPharmaFrankfurt
Celebrations included a garden party with food trucks, table games, a pub quiz with team prizes, instant cameras for a photo collage, and 15 Year gifts. Guests included the CPI Global Compliance Team, Allessa GmbH, Weylchem Innotec GmbH, and Walter Krebs GmbH, with speeches by Head of Operations Dr. Karsten Meyenberg and CFO Heiko Serwe.
#CordenPharmaChenôve
Celebrations included a garden party with a “Burgundy” aperitif dinner, food trucks for lunch, a fun photo booth for taking 15 Year souvenirs, and speeches by Managing Director Yves Michon and CordenPharma Chief Quality & Compliance Officer Will Cashin.
#CordenPharmaCaponago
Celebrations continued 4 times throughout the day & night to cover all shifts, and included a multi-course German lunch or dinner with brezel, speeches by Managing Director Fabrizio Fiordigiglio and VP of Sales Dr. Mimoun Ayoub, followed by a festive garden gazebo for the 15 Year gift distribution of Prosecco and backpacks.
#CordenPharmaBrussels
Celebrations included a boat ride to Brussels City Center, followed by 3 groups taking guided bike or walking tours of secret places along the canal or the Tour & Taxis building. The party finished with a BBQ dinner and speeches from Managing Director Dr. Jean-Luc Dewez and VP General Counsel Nicolas Reischer.
Brittany Hayes joined CordenPharma as Director, Global Highly Potent & Oncology Platform in October 2021, bringing over 20 years of extensive experience in the areas of contract manufacturing (Drug Substance & Drug Product), pharmaceutical and API development, business development, contract management, and organic chemistry.
Prior to joining CordenPharma, Brittany held leadership positions at various Contract Development & Manufacturing Organizations (CDMOs) including Recro, Regis Technologies, DSM/Patheon/Thermo Fisher, Formex, Ricerca, and Azopharma. Most recently, Brittany was Applied Technology Director at Recro, where she was responsible for managing the proposal evaluations and development team, providing technical support to the BD team, creating training for new service offerings, and enhancing new client onboarding & knowledge transfer by liaising with business development executives, technical operations personnel, and project managers. Brittany excels at driving technical decision-making for successful pharmaceutical product development.
Brittany earned her Ph.D. in organic chemistry from Wake Forest University (Winston-Salem, NC) and her B.S. degree in Chemistry from Emory University (Atlanta, GA). She also was an American Heart Association postdoctoral fellow at the University of Illinois at Chicago, Department of Medicinal Chemistry & Pharmacognosy. Brittany has been an active member of the American Chemical Society since 1995.