A liposome is a spherical vesicle of concentric self-assembling lipid bilayers. The liposome can be used as a vehicle for administration of pharmaceutical drugs or nutrients. Liposomes are most often composed of biocompatible and biodegradable lipids excipients such as sphingomyelin, phosphatidylcholine, glycerophospholipids and cholesterols, but may also include other lipids excipients, so long as they are compatible with lipid bilayer structure. Cholesterol, another pharmaceutical additive, can increase stability of a liposome and prevent leakage of a bilayer because its hydroxyl group can interact with the polar heads of the phospholipid bilayer.
For thirty years, CordenPharma’s scientists have mastered the chemical total synthesis of complex phospholipid derivatives from multi-gram to multi-kilogram scale and are renowned for their contract lipid & phospholipid manufacturing expertise. Our large-scale proprietary cGMP manufacturing processes start with (S)-1,2-isopropylideneglycerol ((S)-IPG) and extend over a cascade of optimized and fully-scalable conversions leading to a wide range of phospholipids which support LNP drug delivery formulations used as vehicles for RNA and / or peptides.