Managing Director:

Dr. Till Riehm

Corden BioChem GmbH
Industriepark Hoechst
Brüningstraße 50
D-65929 Frankfurt am Main
Phone: +49 (0)69 305 17641
Fax: +49 (0)69 305 35158

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Core Capabilities

  • Contract Development & Manufacturing Organization (CDMO) of microbial fermentation, technical enzymes and the application of biocatalysis for the synthesis of intermediates and APIs
  • Process development and characterization from initial pilot scale (2 x 3m³) to industrial large-scale up to 120m³-scale, including process validation
  • Capability to handle a wide range of organisms (e.g. fungi, E.coli, Pichia, Bacillus, other yeast) as non-GMO organisms and GMO-organisms up to BSL 1
  • Dedicated cell bank preparation facility and maintenance with redundant equipment and controls
  • On-site anaerobic and aerobic waste treatment
  • Broad range of downstream unit operations from Broth separation via separators (nozzle), cell disruption via homogenisation, concentration via ultrafiltration and reverse osmosis to immobilization of enzymes
  • Enzyme product types
    • Whole cell catalysts
    • Stabilized ultrafiltrates
    • Immoblized enzymes
  • Expertise in development and large-scale production of immobilized enzymes using various carriers
  • Fully controlled fermentation plant using Process Anayltical Technology (PAT)
  • Continous and batch sterilisation
  • Cleaning In Place (CIP) and Sanitization In Place (SIP) for Fermentation and Enzyme plant

Compliance Approvals

  • German authorities, 2013
  • FDA, 2016
  • Kosher / Halal, 2016 / 2017
  • HACCP / IFS can be met


  • DIN EN ISO 14001 Environmental management systems - Requirements with guidance for use (ISO 14001:2009) – 2015
  • DIN EN ISO 50001 Energy management systems - Requirements with guidance for use (ISO 50001:2011) - 2015
  • Occupational Health and Safety Management Systems OSHAS 18001- 2015

Facility Legacy

CordenBioChem, located in Hoechst near Frankfurt, Germany, is one of the world's largest industrial manufacturing partners, with a total fermentation reactor capacity of 3000m³ for biotechnology-derived product supply to the pharmaceutical and fine chemicals industries.

Formerly a manufacturing facility of Sandoz (the generics business of Novartis), CordenBioChem are pioneers in applying green chemistry for intermediates and Active Pharmaceutical Ingredients (APIs), and are one of the largest global producers of 7-ACA (7-aminocephalosporanic acid), a key starting material for cephalosporin synthesis. For sixty years they have implemented and optimized large-scale fermentation, downstream, biocatalysis and synthesis processes with world-class efficiency, quality and reliability. 

Being owned by ICIG, the CordenBioChem facility serves as a connection between the synthetic cGMP capabilities of CordenPharma and the non-GMP manufacture of chemicals in their sister company Weylchem.


  • 1863 - Foundation as “Farbwerke Hoechst AG”
  • 1998 - Aquisition of ‘Fermentationsverbund‘ from Hoechst Marion Roussell (Antibiotics Production) by Biochemie GmbH (affiliate of Novartis)
  • 2003 - Re-Branding to Sandoz, the Generics Division of Novartis
  • 2016 - Aquisition by International Chemical Investor Group to become Corden BioChem GmbH

Technologies / Processes

  • Fermentation
  • Enzyme Technology
  • Biocatalysis
  • Purification
  • Synthesis
  • Separation
  • Homogenisation
  • Ultrafiltration
  • Pasteurisation
  • Organic solvent handling & recovery 

 Equipment Details    

  • Large-scale fermenters up to 120m³
  • Pilot plant
  • Batch and continuous sterilisation
  • Downstream with separators, homogenisator, bead mill, ultrafiltration unit, heat exchanger, handling of solvents, immobilisation vessels, filling station of solids and liquids
  • Delta V Process Control System (PCS)


  • One of the largest fermentation CDMOs worldwide
  • Total fermenter volume 3000m³
  • Fermenter sizes: 19x 120m³, 14x40m³, 12x12m³, 18x 3m³, 28x 0.8m³
  • Enzyme capacity up to 1000t

Other Specialties

  • Immobilized Enzymes
  • Biocatalysis
  • 7-ACA (enzymatic 7-aminocephalosporanic acid)
  • Sterile Cephalosporins
  • Analytical Services
    • Chemical & physical laboratory
    • Instrumental lab (HPLC & GC)
    • Microbiology, sterility testing & environmental monitoring