CordenPharma’s scientists have mastered the chemical total synthesis of complex phospholipid derivatives from multi-gram to multi-kilogram scale. Our large-scale cGMP manufacturing processes start with (S)-1,2-isopropylideneglycerol ((S)-IPG) and extend over a cascade of optimised and fully scalable conversions leading to a wide range of phospholipids such as, but not limited to:


DLPA
DSPG, Na
DMPE
DPPC
DSPC
S/P-lyso-PC
DPyPE
POPG, Na,
POPC
DOPE
MPEG2000-DSPE
MPEG750-DSPE
MPEG5000-DSPE
MPEG2000-DPPE
MPEG2000-DMPE




CordenPharma also pioneered the chemistry and large-scale manufacture of MPEG-conjugated phospholipids which can be accessed through the same synthesis cascade, rendering them superior quality products in sensitive liposome formulation processes.

In addition, standard cationic phospholipids such as DODMA and DOTAP can be made available in cGMP and R&D grade qualities.  

Please refer to CordenPharma’s Phospholipid Brochure for more details. A wide selection of readily available phospholipids suitable for Research and Discovery is available for purchase in convenient 1g and 10g pack sizes (please refer to our Lipid Price List for more details).

CordenPharma also offers cGMP contract manufacturing of proprietary phospholipids, monoglycerols, diacylglycerols, sphingosines, ceramides and engineered cationic lipids. Furthermore, CordenPharma is in a unique position to draw upon this combination of chemistry capabilities to synthesize novel liposome conjugate components conjugated with functional peptides or carbohydrates for targeted drug delivery.

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