By virtue of our technological strengths CordenPharma is a reliable supplier of highly advanced building blocks on a multi-kg to multi-ton scale. Our portfolio includes amino acid derivatives (AADs) such as Fmoc-protected AADs and unusual AADs as well as pseudoproline dipeptides, nucleoside building blocks and other API chiral building blocks like alcohols and hydroxyesters.
The quality and breath of CordenPharma’s AADs and pseudoproline product line was recognized in 2011 with the Frost & Sullivan Award for Product Line Strategy Excellence in this category.
Pseudoproline Dipeptides
In advanced peptide synthesis Mutter’s pseudoproline dipeptides*, serine, and threonine derived Fmoc protected building blocks play an increasingly important role in overcoming aggregation and low-solubility effects in the synthesis of long and difficult sequences.
CordenPharma was the first worldwide supplier offering pseudoprolines in multi-kg quantities. Today our pseudoproline product line comprises 28 different dipeptides, the most comprehensive offering of dipeptides meeting the highest quality standard for peptide cGMP production. CordenPharma teamed up with Neuland Laboratories to further improve manufacturing processes for multi-kg production at the lowest possible price. Our pseudoprolines are also readily available as standard catalogue products (refer to our pseudoproline price list for small pack units up to 100g).
* T. Woehr, M. Mutter (1995). Pseudo-prolines in peptide synthesis: direct insertion of serine and threonine derived oxazolidines in dipeptides. Tetrahedron Lett. 36, 3847-3848.
Standard Fmoc-protected Amino Acid Derivatives
The commercial launch of the in-house produced peptide-based anti-HIV drug Fuzeon®, the world’s only peptide ever produced in multi-tonne quantities, was supported with internally sourced amino acid derivatives of highest purity. CordenPharma’s AADs are recognized for their batch-to-batch consistent quality and extensive analytical characterization. Please refer to our AAD Brochure listing amino acid derivatives suitable for peptide cGMP production available in bulk quantities.
Unusual Amino Acid Derivatives
CordenPharma employs efficient and versatile enamide synthesis routes and asymmetric actalytical hydrogenation technologies to access a wide range of unusual amino acids in bulk quantities including:
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Numerous glycine and alanine derivatives
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D-amino acids
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Di-amino acid derivatives
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Amino di-carboxylic acids
Nucleoside Building Blocks
Oligonucleotides are chemically synthesized using phosphoramidite nucleosides or, to a lesser extent, non-nucleosidic compounds. CordenPharma has experience in developing and optimizing processes for synthesizing tightly quality-controlled phosphoramidites and offers custom manufacturing services for your proprietary building blocks.
API - Chiral Building Blocks
CordenPharma has also successfully developed the commercial production of different chiral alcohols, and hydroxy esters starting from ketones based on worldwide patents which are exclusively licensed from our development partners. With CordenPharma’s network of multi-purpose plants we are your quality choice for the custom synthesis of downstream chemistry using chiral alcohols based on:
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Latest enzyme technology
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Extremely high enantiomeric purity (>99,0 % and higher)
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Availability from lab to commercial scale (up to 100 mt’s)
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Cost-effective development of custom manufacturing molecules
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Safety testing and evaluation support for contracted customers